testosterone

Testosterone, Diabetes Risk, and Diabetes Prevention in Men

Testosterone, Diabetes Risk, and Diabetes Prevention in Men

Testosterone, Diabetes Risk, and Diabetes Prevention in Men. Yeap BB, Wittert GA. Endocrinol Metab Clin North Am. 2022 Mar;51(1):157-172. doi: 10.1016/j.ecl.2021.11.004. Epub 2022 Feb 8. PMID: 35216714.
Contact: Gary Wittert

Lingering effects of testosterone injections lead to long delay in recovery of male reproductive function

Lingering effects of testosterone injections lead to long delay in recovery of male reproductive function

Recovery of Male Reproductive Function After Ceasing Prolonged Testosterone Undecanoate Injections
Handelsman DJ, Desai R, Conway AJ, Shankara-Narayana N, Stuckey BG, Inder WJ, Grossmann M, Yeap BB, Jesudason D, Ly LP, Bracken K, Wittert GA. Eur J Endocrinol. 2022 Jan 1:EJE-21-0608.R2. doi: 10.1530/EJE-21-0608. Online ahead of print.PMID: 35000898
Contact: Gary Wittert

Testosterone concentration associated with dementia in men: The UK Biobank prospective cohort study

Testosterone concentration associated with dementia in men: The UK Biobank prospective cohort study

Lower serum testosterone concentrations are associated with a higher incidence of dementia in men: The UK Biobank prospective cohort study.
Marriott RJ, Murray K, Flicker L, Hankey GJ, Matsumoto AM, Dwivedi G, Antonio L, Almeida OP, Bhasin S, Dobs AS, Handelsman DJ, Haring R, O'Neill TW, Ohlsson C, Orwoll ES, Vanderschueren D, Wittert GA, Wu FCW, Yeap BB. Alzheimers Dement. 2022 Jan 3. doi: 10.1002/alz.12529. Online ahead of print.PMID: 34978125
Contact: Gary Wittert

Relevance of testosterone & SHBG in cardiovascular disease in men

Relevance of testosterone & SHBG in cardiovascular disease in men

Associations of Serum Testosterone and Sex Hormone-Binding Globulin With Incident Cardiovascular Events in Middle-Aged to Older Men.
Yeap BB, Marriott RJ, Antonio L, Raj S, Dwivedi G, Reid CM, Anawalt BD, Bhasin S, Dobs AS, Handelsman DJ, Hankey GJ, Haring R, Matsumoto AM, Norman PE, O'Neill TW, Ohlsson C, Orwoll ES, Vanderschueren D, Wittert GA, Wu FCW, Murray K. Ann Intern Med. 2021 Dec 28. doi: 10.7326/M21-0551. Online ahead of print.PMID: 34958606
Contact: Gary WIttert

Low circulating SHBG in men and increased risk of myocardial infarction

Low circulating SHBG in men and increased risk of myocardial infarction

Associations of serum testosterone and sex hormone-binding globulin with incident cardiovascular events in middle-aged to older men.
Yeap BB, Marriott RJ, Antonio L, Raj S, Dwivedi G, Reid CM, Anawalt BD, Bhasin S, Dobs AS, Handelsman DJ, Hankey GJ, Haring R, Matsumoto AM, Norman PE, O'Neill TW, Ohlsson C, Orwoll ES, Vanderschueren D, Wittert GA, Wu FCW, Murray K. Ann Intern Med. 2021 Dec 28. doi: 10.7326/M21-0551. Epub ahead of print. PMID: 34958606.
Contact: Gary.Wittert

Clinical review of inadequate nutrition and excessive energy expenditure on testosterone in men

Clinical review of inadequate nutrition and excessive energy expenditure on testosterone in men

Dysregulation of the Hypothalamic-Pituitary-Testicular Axis due to Energy Deficit.
Grossmann M, Wittert GA.J Clin Endocrinol Metab. 2021 Jul 15:dgab517. doi: 10.1210/clinem/dgab517. Online ahead of print.PMID: 34264314
Contact: Gary Wittert

T4DM Sub-study finds testosterone increased volumetric cortical bone density in men>50 years

T4DM Sub-study finds testosterone increased volumetric cortical bone density in men>50 years

Effect of Testosterone treatment on bone microarchitecture and bone mineral density in men: a two-year RCT.Ng Tang Fui M, Hoermann R, Bracken K, Handelsman DJ, Inder WJ, Stuckey BGA, Yeap BB, Ghasem-Zadeh A, McLachlan R, Robledo KP, Jesudason D, Zajac JD, Wittert GA, Grossmann M.
.J Clin Endocrinol Metab. 2021 Mar 8:dgab149. doi: 10.1210/clinem/dgab149.
Contact: Gary Wittert

Testosterone + lifestyle program reduces the risk of T2DM in men

Testosterone + lifestyle program reduces the risk of T2DM in men

Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial.
Wittert G, Bracken K, Robledo KP, Grossmann M, Yeap BB, Handelsman DJ, Stuckey B, Conway A, Inder W, McLachlan R, Allan C, Jesudason D, Fui MNT, Hague W, Jenkins A, Daniel M, Gebski V, Keech A. Lancet Diabetes Endocrinol. 2021 Jan;9(1):32-45. doi: 10.1016/S2213-8587(20)30367-3.
Contact: Gary Wittert

Mortality of men: The role of testosterone and sex hormone-binding globulin

Mortality of men: The role of testosterone and sex hormone-binding globulin

Serum testosterone is inversely, and sex hormone-binding globulin directly, associated with all-cause mortality in men
Yeap BB, Marriott RJ, Antonio L, Chan YX, Raj S, Dwivedi G, Reid CM, Anawalt BD, Bhasin S, Dobs AS, Hankey GJ, Matsumoto AM, Norman PE, O'Neill TW, Ohlsson C, Orwoll ES, Vanderschueren D, Wittert GA, Wu FCW, Murray K. J Clin Endocrinol Metab. 2020 Oct 16:dgaa743. doi: 10.1210/clinem/dgaa743.
Contact: Bu Yeap

Time to rethink the link between testosterone and masculinity

New research by the Freemasons Centre for Male Health and Wellbeing has shown the public perception that ‘too much testosterone’ increases stereotypical masculine traits in men might not be true at all.

The Australian-first study analysed testosterone levels of more than 500 men aged 35 and older and assessed their self-perceptions of masculinity through a questionnaire that rated six different indicators of masculinity.

Research leader and endocrinologist, Professor Gary Wittert, said the results showed no relationship between testosterone and masculinity.

“Masculinity traditionally tends to be characterised by traits such as toughness, emotional control, physical strength, competitiveness and sexual competency,” Professor Wittert said.

“The six areas of self-perceived masculinity evaluated in this study were physical strength, optimism, sexuality, self-reliability, family responsibility and ability to take action. We found there was no link between the participants’ self-perceptions of these traits and their testosterone concentration.”

Professor Wittert said the study clearly showed that psychosocial factors and physical disorders are the variants underpinning self-perceived masculinity.

“The key factors negatively impacting scores included a history of anxiety, being without a partner and most significantly living with moderate to severe erectile dysfunction,” he said.

Men with bigger waistlines and varying levels of erectile dysfunction were less confident sexually and less optimistic, while males with partners viewed themselves as physically stronger and more responsible than those who had been widowed or divorced.

“The notion that typical traits of masculinity are linked to testosterone and are risk factors for poor health no longer stand up to scrutiny,” Prof Wittert said.

“Accumulating evidence suggests that aspects of typical masculinity might be associated with better health and health outcomes for men,” Prof Wittert said.

Enquiries to: Professor Gary Wittert

Key reference: Peel, A., Martin, S., Vincent, A., Turnbull, D., Wang, X., McGee, M., Jesudason, D., Chambers, S., & Wittert, G. (2020). Relationship between Testosterone and Self-Perceived Masculinity in an Australian Cohort of Community-Dwelling Men. Journal of Men’s Health, 16(4), e28-e44. https://doi.org/10.31083/jomh.v16i4.252

Influence of demographic and lifestyle factors on testosterone concentration

Influence of demographic and lifestyle factors on testosterone concentration

Sociodemographic, lifestyle and medical influences on serum testosterone and sex hormone-binding globulin in men from UK Biobank
Yeap BB, Marriott RJ, Antonio L, Bhasin S, Dobs AS, Dwivedi G, Flicker L, Matsumoto AM, Ohlsson C, Orwoll ES, Raj S, Reid CM, Vanderschueren D, Wittert GA, Wu FCW, Murray K. Clin Endocrinol (Oxf). 2020 Sep 26. doi: 10.1111/cen.14342.
Contact: Bu Yeap