The androgen receptor is a tumor suppressor in estrogen receptor-positive breast cancer
Hickey TE, Selth LA, Chia KM, Laven-Law G, Milioli HH, Roden D, Jindal S, Hui M, Finlay-Schultz J, Ebrahimie E, Birrell SN, Stelloo S, Iggo R, Alexandrou S, Caldon CE, Abdel-Fatah TM, Ellis IO, Zwart W, Palmieri C, Sartorius CA, Swarbrick A, Lim E, Carroll JS, Tilley WD. Nat Med. 2021 Jan 18. doi: 10.1038/s41591-020-01168-7.
Contact: Wayne Tilley
Maximising the effectiveness of psychological treatment for young men with psychosis
The metacognitive training (MCT) programme is an effective psychological treatment for reducing delusional symptoms and may be particularly effective in young men. This is due to MCT’s unique focuses on the underlying problematic thinking styles responsible for delusions, rather than directly challenging these beliefs, which makes it a less confrontational approach.
Contact: Ryan Balzan
This program’s focus is on de-stigmatising psychosis and its youth-friendly audio-visual delivery to help foster a strong therapeutic alliance that will also help young men stay engaged with therapy and could improve their long-term prognosis.
Deep decision-making for prostate tumour Gleason Score 7
This project, which brings together expertise in clinical pathology, machine learning, statistics and computer science, aims to use a Deep Learning approach to analyse prostate biopsy images to better distinguish between Gleason 3+4 and 4+3 more reliably.
Contact: Dr Gobert lee
COVID-19 and Androgen Deprivation Therapy
Androgen deprivation therapy in unlikely to be effective for treatment of COVID-19
O'Callaghan ME, Jay A, Kichenadasse G, Moretti KL. Ann Oncol. 2020 Sep 30:S0923-7534(20)42464-0. doi: 10.1016/j.annonc.2020.09.014.
Contact: Michael O’Callaghan