program

Fatty acid oxidation inhibition to treat advanced prostate cancer

Fatty acid oxidation inhibition to treat advanced prostate cancer

With progressed prostate cancer, men are no longer responding to the standard anti-androgen drug therapy. While developing new drugs often can take 15 years, this program will reduce this timeframe by aiming to re-purpose existing lipid-modifying medicines. We aim to take our laboratory findings into a proof-of-concept clinical trial to test whether trimetazidine is safe and effective in treating men on ADT, to prevent or delay the onset of lethal castrate resistant prostate cancer.

Through this trial we aim for a potential new therapeutic approach using existing drugs used to treat cardio-metabolic disease to prevent lethal prostate cancer, reduced drug-related toxicities in men being treated for prostate cancer, and Improved length and quality of life for men living with advanced prostate cancer.

Contact: Dr Zeyad Nassar

Improving precision medicine for men being treated for prostate cancer

Improving precision medicine for men being treated for prostate cancer

The aim of this project is to determine the impact of commonly prescribed classes of concomitant non-cancer medicines (i.e.antibiotics, proton pump inhibitors, lipid- and blood glucose-lowering medications) on the efficacy of treatments for metastatic prostate cancer. To achieve this, we will exploit large clinical trial datasets, sophisticated data analytic methods (e.g. machine learning) and biologically-informed models.

Contact: Dr Ashley Hopkins

Digitally driven pathways to optimise use and outcomes of primary care for men

Digitally driven pathways to optimise use and outcomes of  primary care for men

This research aims to translate the Centre’s research into an impactful health service integration program targeting the patient-GP interface, arming men with the knowledge, motivation, and agency to recognize symptoms and health behaviours as prompts to engage with primary health care services, and providing men and GPs with tools that optimise the outcomes of that engagement.

Contact: Professor Gary Wittert

Improving uptake of prostate cancer screening in men from culturally and linguistically diverse backgrounds.

Improving uptake of prostate cancer screening in men from  culturally and linguistically diverse backgrounds.

We will partner with researchers and community outreach officers at Cancer Council SA (lead by Dr Jess Loyer), the Multicultural Communities of South Australia Men’s Group who are investigating barriers to engagement with cancer control programs among CALD communities.

This program aims to adapt the current RACGP prostate cancer screening decision-making tool to be culturally sensitive and meet the needs of men from CALD backgrounds and improve the uptake of PSA screening which will facilitate early detection and treatment/monitoring of prostate cancer.

Contact: Dr Norma Bulamu

Clinical workforce development: Healthy Male-Bellberry Clinical Training Fellowship in Men’s Health

Clinical workforce development:  Healthy Male-Bellberry Clinical  Training Fellowship in Men’s Health

This program is a 1-year South-Australian-based clinical training fellowship in andrology and Men’s Health, delivered in association with Healthy Male (Andrology Australia) to develop a dedicated men’s health clinical sub-specialty workforce and services.

Contact: Professor Gary Wittert

Masculinity and mental health: shaping the attitudes, behaviours and education of young men through sport

 Masculinity and mental health: shaping the attitudes, behaviours and education of young men through sport

This Program aims to listen to the voices of young males around mental health and wellbeing within masculinised sporting cultures, explore the way in which sporting clubs work with young males around mental health and wellbeing, investigate the way in which masculinities are created, maintained, and perpetuated within masculinized sporting clubs, and promote the importance of mental health and wellbeing as a key element of sporting club culture.

Contact: Murray Drummond

Maximising the effectiveness of psychological treatment for young men with psychosis

Maximising the effectiveness of psychological treatment for young men with psychosis

The metacognitive training (MCT) programme is an effective psychological treatment for reducing delusional symptoms and may be particularly effective in young men. This is due to MCT’s unique focuses on the underlying problematic thinking styles responsible for delusions, rather than directly challenging these beliefs, which makes it a less confrontational approach.

Contact: Ryan Balzan

This program’s focus is on de-stigmatising psychosis and its youth-friendly audio-visual delivery to help foster a strong therapeutic alliance that will also help young men stay engaged with therapy and could improve their long-term prognosis.

Using COVID-19 pandemic data on mental and physical health to help Australian men

Using COVID-19 pandemic data on mental and physical health to help Australian men

Using COVID-19 response data collected from men in the Florey Adelaide Male Ageing Study (FAMAS) & the North West Adelaide Health Study (NWAHS), the aim is to develop a detailed understanding of the acute and medium-term economic drivers of mental and physical health maintenance in well-characterised, representative cohorts of men.

Contact: Prof Robert Adams

We will continue to collect the stories/accounts of male veteran suicide from families or survivors, and use this to identify i) the service-related contexts, ii) post service-related contexts, iii) the family and social support elements, iv) the institutional support elements, and v) mental and physical health elements of men’s suicide or attempted suicide.

Veteran suicide: Men, Health, Service

Veteran suicide: Men, Health, Service

This program hopes to continue to formally define the relationship between the ideals of manhood, the impacts of military training and service and their relationship with poor mental health or moral injury leading to suicide attempt or death.

Contact: Ben Wadham

We will continue to collect the stories/accounts of male veteran suicide from families or survivors, and use this to identify i) the service-related contexts, ii) post service-related contexts, iii) the family and social support elements, iv) the institutional support elements, and v) mental and physical health elements of men’s suicide or attempted suicide.

Translation of knowledge into practice: building the wellbeing of Aboriginal men and boys

Translation of knowledge into practice: building the wellbeing of Aboriginal men and boys

The aim of this program is to translate ecological maps of risk and protective factors for wellbeing in Aboriginal men and boys into health promotion and prevention activities in SA through trialling the use of an ecological framework and knowledge interface processes as tools to improve the wellbeing of First Nations men and boys.

The program will be led by Aboriginal academics and informed by Indigenous knowledge of health and wellbeing. Further, community engagement will empower communities to participate in the development of resources to support the social and emotional wellbeing of their men and boys.

Contact: Tamara Mackean

Investigating the effects of androgen therapies on the prostate immune system

Investigating the effects of androgen therapies on the prostate immune system

Immunotherapy approaches for prostate cancer have been largely unsuccessful, despite many clinical trials. We propose that harnessing the immune system to treat prostate cancer first requires a better understanding of the unique biology of this disease. The objective of this research program is to investigate the interplay between androgen receptor signalling and immunity in prostate cancer

Contact: A/Prof Luke Selth