cancer

Improved tumor cell invasiveness measurement using digital holographic microscopy

Improved tumor cell invasiveness measurement using digital holographic microscopy

Optical Cellular Micromotion: A new paradigm to measure tumor cells Invasion within gels mimicking the 3D tumor environments.
Guo Z, Yang CT, Chien CC, Selth LA, Bagnaninchi PO, Thierry B. Small Methods. 2022 Jun 28:e2200471. doi: 10.1002/smtd.202200471.
Contact: Luke Selth

DNA-PK has novel role in Metabolism by Regulating Glycolysis in Prostate Cancer

DNA-PK has novel role in Metabolism by Regulating Glycolysis  in Prostate Cancer

Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration Resistant Prostate Cancer.
Dylgjeri E, Kothari V, Shafi AA, Semenova G, Gallagher PT, Guan YF, Pang A, Goodwin JF, Irani S, McCann JJ, Mandigo AC, Chand S, McNair CM, Vasilevskaya I, Schiewer MJ, Lallas CD, McCue PA, Gomella LG, Seifert EL, Carroll JS, Butler LM, Holst J, Kelly WK, Knudsen KE.
Contact: Lisa Butler

Fatty acid oxidation inhibition to treat advanced prostate cancer

Fatty acid oxidation inhibition to treat advanced prostate cancer

With progressed prostate cancer, men are no longer responding to the standard anti-androgen drug therapy. While developing new drugs often can take 15 years, this program will reduce this timeframe by aiming to re-purpose existing lipid-modifying medicines. We aim to take our laboratory findings into a proof-of-concept clinical trial to test whether trimetazidine is safe and effective in treating men on ADT, to prevent or delay the onset of lethal castrate resistant prostate cancer.

Through this trial we aim for a potential new therapeutic approach using existing drugs used to treat cardio-metabolic disease to prevent lethal prostate cancer, reduced drug-related toxicities in men being treated for prostate cancer, and Improved length and quality of life for men living with advanced prostate cancer.

Contact: Dr Zeyad Nassar

Improving precision medicine for men being treated for prostate cancer

Improving precision medicine for men being treated for prostate cancer

The aim of this project is to determine the impact of commonly prescribed classes of concomitant non-cancer medicines (i.e.antibiotics, proton pump inhibitors, lipid- and blood glucose-lowering medications) on the efficacy of treatments for metastatic prostate cancer. To achieve this, we will exploit large clinical trial datasets, sophisticated data analytic methods (e.g. machine learning) and biologically-informed models.

Contact: Dr Ashley Hopkins

An androgen receptor switch underlies lineage infidelity in treatment-resistant prostate cancer.

An androgen receptor switch underlies lineage infidelity in treatment-resistant prostate cancer.

An androgen receptor switch underlies lineage infidelity in treatment-resistant prostate cancer.
Davies A, Nouruzi S, Ganguli D, Namekawa T, Thaper D, Linder S, Karaoğlanoğlu F, Omur ME, Kim S, Kobelev M, Kumar S, Sivak O, Bostock C, Bishop J, Hoogstraat M, Talal A, Stelloo S, van der Poel H, Bergman AM, Ahmed M, Fazli L, Huang H, Tilley W, Goodrich D, Feng FY, Gleave M, He HH, Hach F, Zwart W, Beltran H, Selth L, Zoubeidi A.
Nat Cell Biol. 2021 Sep;23(9):1023-1034. doi: 10.1038/s41556-021-00743-5. Epub 2021 Sep 6.PMID: 34489572
Contact: Luke Selth

FCMHW officially launched by His Excellency the Honourable Hieu Van Le AC Governor of SA

Ms Sheralyn Holmes, Company Secretary of FCMHW Ltd welcomed His Excellency the Honourable Hieu Van Le AC Governor of South Australia and 120+ guests to the South Australian Health and Medical Research Institute for the official launch the SA Division of the Freemasons Centre for Male Health & Wellbeing on Monday 8 February.   

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We were honoured to have Jack Buckskin, a proud Kaurna Narungga man, welcome us to Country. Jack is a young leader in the community who is dedicated to learning and passing on his knowledge and language of the Adelaide Plains to future generations of Kaurna people. He shared his experiences growing up as a boy, a young man and now as a dedicated father and described how learning to dance gave him his strong connection to his culture.

His Excellency, Patron in Chief of the former Freemasons Foundation Centre for Men’s Health and current Patron of Masonic Charities, acknowledged the importance of and the quality and impact of the research the Centre has carried out and how proud he is that Australia’s only multi-disciplinary male health research centre calls SA and NT home.

Professor Steve Wesselingh, Executive Director of SAHMRI and Director of the Freemasons Centre for Male Health and Wellbeing Ltd, spoke to the significance of the Centre working across SAHMRI’s themes addressing the significant health challenges facing our community – cancer, chronic disease, mental health, social wellbeing, and, as COVID has highlighted, infectious diseases to ensure a gender lens is applied to how we better understand, educate about and reduce the burden of these conditions and importantly improve on our delivery of health services. 

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Grand Master of Freemasons of SA/NT, and Chairman of the Board of the FCMHW Ltd and former Director of Masonic Charities, Dr Neil Jensen MBBS FRACGP FAAETS (USA) Colonel (Retrd), spoke to the importance of benevolence to Freemasons. Freemasons are taught to be ever alert to the needs of others and to promote happiness. This centre is an iteration of our desire for a better tomorrow. “Through the work of this Centre, we see our great masonic family providing tangible help for our fellow citizens: men, women and children.”

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Professor Gary Wittert, Director of the FCMHW SA Division, acknowledged the now 13 year history of the Centre and the major investment of the University of Adelaide and Freemasons of SA/NT through the Freemasons Foundation, and now Masonic Charities, that has led to the success and growth of the Centre from a handful to now more than 50 researcher. He thanked those involved and spoke with great pride of the many young outstanding researchers and students who the Centre has supported. He cherry picked just some examples of how the Centre’s research has influenced and changed practice.

L to R:  Professor Michael Liebelt, Mr Robert Clyne OAM OS, Dr Neil Jensen, Ms Sheralyn Holmes, Professor Steven Wesselingh, His Excellency the Honourable Hieu Van Le AC Governor of South Australia, and Professor Gary Wittert.

L to R: Professor Michael Liebelt, Mr Robert Clyne OAM OS, Dr Neil Jensen, Ms Sheralyn Holmes, Professor Steven Wesselingh, His Excellency the Honourable Hieu Van Le AC Governor of South Australia, and Professor Gary Wittert.

The formal part of the event concluded with His Excellency and Dr Jensen unveiling a plaque commemorating the establishment of the Centre which will be placed in the Hall of Fame in the Grand Lodge building of Freemasons of SA and NT on North Terrace. 

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FCMHW thanks Morgan Stanley Australia for its generous sponsorship of this event.

ELOVL5: Inching closer to a new therapeutic strategy for prostate cancer

ELOVL5: Inching closer to a new therapeutic strategy for prostate cancer

ELOVL5 is a critical and targetable fatty acid elongase in prostate cancer
Centenera MM, Scott JS, Machiels J, Nassar ZD, Miller DC, Zininos I, Dehairs J, Burvenich IJG, Zadra G, Chetta P, Bango C, Evergren E, Ryan NK, Gillis JL, Mah CY, Tieu T, Hanson AR, Carelli R, Bloch K, Panagopoulos V, Waelkens E, Derua R, Williams ED, Evdokioou A, Cifuentes-Rius A, Voelcker NH, Mills IG, Tilley WD, Scott AM, Loda M, Selth LA, Swinnen JV, Butler LM. Cancer Res. 2021 Feb 5:canres.2511.2020. doi: 10.1158/0008-5472.CAN-20-2511.
Contact: Maggie Centenera

Launch of the Freemasons Centre for Male Health and Wellbeing - SA Division

Press Release:

The Freemasons Centre for Male and Health and Wellbeing (FCMHW) is a research alliance involving the Masonic Charities and The University of Adelaide and SAHMRI in SA and the Menzies School of Health Research in the NT

The Founding member of the former Freemasons Foundation Centre for Men’s Health and Director since 2012, Professor Gary Wittert (The University of Adelaide and SAHMRI), says the FCMHW brings together globally recognised leaders in male health research.

Top priorities for the Centre’s SA Division include prostate cancer and pre-conception health as well as a focus on the common chronic conditions affecting men such as obesity, diabetes, depression, sexual health and troublesome lower urinary tract symptoms.

As well generating new knowledge as to the causes of and optimal way to treat men for these conditions, a central aim of the alliance is to ensure research translates into real world changes in clinical and public health practices.

“Our work to date has shown clearly that men do use health services and they do care about their health,” Prof Wittert said.

“Great improvements can be made, relatively simply, through changes that ensure our health care system is catering for and communicating to men more effectively.”  This will be a particular focus for the Centre over the coming years.

The FCMHW SA Division is being officially launched today, following the successful launch of the Northern Territory division in November 2020.

The Centre is the evolution of the Freemasons Foundation Centre for Men’s Health which was established in 2007 and maintained through a $7.2 million dollar partnership between the Freemasons Foundation and the University of Adelaide.

Masonic Charities, the charitable arm of Freemasons SA/NT is donating a minimum of $1.8 million over three years to the new Centre, funds that will be matched collectively by the research alliance partners.

The Grand Master of the Freemasons SA/NT, Dr Neil Jensen, said the new centre will build on the foundation laid by its predecessor with an increased capacity to improve male health outcomes due to a stronger, broader network. “We started at a time when men’s health was not really spoken about and it’s now in a far better place,” Dr Jensen said.

“We’re very proud of what’s been achieved so far, but there’s still much work to be done and the Centre will play a pivotal role in the future.”  We are often asked, as Freemasons, what do we do.  Benevolence and serving the communities in which we live are core to Freemasonry. The Centre is a perfect example of the contribution made by Freemasons of SA/NT particularly given the positive impact that the Centre’s work will have for males, their families and communities.  

The official launch of the SA Division of the Centre will be held at SAHMRI on Monday 8 February.

Culturing pancreatic tumour tissue provides novel ways to improve cancer knowledge

Culturing pancreatic tumour tissue provides novel ways to improve cancer knowledge

Ex vivo culture of intact human patient derived pancreatic tumour tissue.
Kokkinos J, Sharbeen G, Haghighi KS, Ignacio RMC, Kopecky C, Gonzales-Aloy E, Youkhana J, Timpson P, Pereira BA, Ritchie S, Pandzic E, Boyer C, Davis TP, Butler LM, Goldstein D, McCarroll JA, Phillips PA. Sci Rep. 2021 Jan 21;11(1):1944. doi: 10.1038/s41598-021-81299-0.
Contact: Lisa Butler