lipid metabolism

Major grant funding to progress lipid-based therapies to treat prostate cancer

Congratulations to members of the Lipids and Prostate Cancer Laboratory (University of Adelaide) at SAHMRI on their major grant funding and appointments.

Dr Zeyad Nassar (pictured left), who was recently appointed as a Post-doctoral Research Fellow at the South Australian Immunogenomics Cancer Institute (SAIGENCI) has been awarded a prestigious and highly competitive grant from the US Department of Defense. The funding worth more than $1Mi over three years will be used to advance drug development and trialing of lipid-based therapies as a new strategy to treat prostate cancer.

Dr Shanice Mah (pictured right), who recently completed her PhD in the Centre and has been awarded a Prostate Cancer Foundation of Australia Future Leaders award of $100,000 to support her lipids and prostate cancer program. (Salary and laboratory costs for 12 months).  

We also congratulate Professor Lisa Butler (pictured centre) on her appointment as Lead Associate of the South Australian Immunogenomics Cancer Institute.

Prostate cancer cell growth is influenced by cholesterol levels

Prostate cancer cell growth is influenced by cholesterol levels

Prostate cancer cell proliferation is influenced by LDL-cholesterol availability and cholesteryl ester turnover.
Raftopulos NL, Washaya TC, Niederprüm A, Egert A, Hakeem-Sanni MF, Varney B, Aishah A, Georgieva ML, Olsson E, Dos Santos DZ, Nassar ZD, Cochran BJ, Nagarajan SR, Kakani MS, Hastings JF, Croucher DR, Rye KA, Butler LM, Grewal T, Hoy AJ. Cancer Metab. 2022 Jan 15;10(1):1. doi: 10.1186/s40170-021-00278-1.PMID: 35033184
Contact: Lisa Butler

ELOVL5: Inching closer to a new therapeutic strategy for prostate cancer

ELOVL5: Inching closer to a new therapeutic strategy for prostate cancer

ELOVL5 is a critical and targetable fatty acid elongase in prostate cancer
Centenera MM, Scott JS, Machiels J, Nassar ZD, Miller DC, Zininos I, Dehairs J, Burvenich IJG, Zadra G, Chetta P, Bango C, Evergren E, Ryan NK, Gillis JL, Mah CY, Tieu T, Hanson AR, Carelli R, Bloch K, Panagopoulos V, Waelkens E, Derua R, Williams ED, Evdokioou A, Cifuentes-Rius A, Voelcker NH, Mills IG, Tilley WD, Scott AM, Loda M, Selth LA, Swinnen JV, Butler LM. Cancer Res. 2021 Feb 5:canres.2511.2020. doi: 10.1158/0008-5472.CAN-20-2511.
Contact: Maggie Centenera