Overcoming enzalutamide resistance in metastatic prostate cancer by targeting sphingosine kinase.
Lin HM, Mak B, Yeung N, Huynh K, Meikle TG, Mellett NA, Kwan EM, Fettke H, Tran B, Davis ID, Mahon KL, Zhang A, Stockler MR, Briscoe K, Marx G, Crumbaker M, Stricker PD, Du P, Yu J, Jia S, Scheinberg T, Fitzpatrick M, Bonnitcha P, Sullivan DR, Joshua AM, Azad AA, Butler LM, Meikle PJ, Horvath LG.
EBioMedicine. 2021 Oct 14;72:103625. doi: 10.1016/j.ebiom.2021.103625. PMID: 34656931.
Contact: Lisa Butler
Lipids used in different IVF products may impact outcome
Albumin used in human IVF contain different levels of lipids and modify embryo and fetal growth in a mouse model. Zander-Fox D, Villarosa L, McPherson NO.J Assist Reprod Genet. 2021 Jun 11. doi: 10.1007/s10815-021-02255-5. PMID: 34114110Z
Contact: Nicole McPherson
Study extends evidence on circulating fats and clinical outcomes for men with prostate cancer
Aberrations in circulating ceramide levels are associated with poor clinical outcomes across localised and metastatic prostate cancer. Lin HM, Huynh K, Kohli M, Tan W, Azad AA, Yeung N, Mahon KL, Mak B, Sutherland PD, Shepherd A, Mellett N, Docanto M, Giles C, Centenera MM, Butler LM, Meikle PJ, Horvath LG.
Prostate Cancer Prostatic Dis. 2021 Mar 21. doi: 10.1038/s41391-021-00338-z.
Contact: Lisa Butler
ELOVL5: Inching closer to a new therapeutic strategy for prostate cancer
ELOVL5 is a critical and targetable fatty acid elongase in prostate cancer
Centenera MM, Scott JS, Machiels J, Nassar ZD, Miller DC, Zininos I, Dehairs J, Burvenich IJG, Zadra G, Chetta P, Bango C, Evergren E, Ryan NK, Gillis JL, Mah CY, Tieu T, Hanson AR, Carelli R, Bloch K, Panagopoulos V, Waelkens E, Derua R, Williams ED, Evdokioou A, Cifuentes-Rius A, Voelcker NH, Mills IG, Tilley WD, Scott AM, Loda M, Selth LA, Swinnen JV, Butler LM. Cancer Res. 2021 Feb 5:canres.2511.2020. doi: 10.1158/0008-5472.CAN-20-2511.
Contact: Maggie Centenera
Optimising tissues for laser-based lipid analysis during mass spectrometry
Removal of optimal cutting temperature (O.C.T.) compound from embedded tissue for MALDI imaging of lipids
Truong JXM, Spotbeen X, White J, Swinnen JV, Butler LM, Snel MF, Trim PJ. Anal Bioanal Chem. 2021 Feb 9. doi: 10.1007/s00216-020-03128-z.
Contact: Jacob Truong
Review: Fatty acid metabolism in cancer
The diversity and breadth of cancer cell fatty acid metabolism.
Nagarajan SR, Butler LM, Hoy AJ.
Cancer Metab. 2021 Jan 7;9(1):2. doi: 10.1186/s40170-020-00237-2. (Review)
Contact: Lisa Butler