Lipidomic profiling of clinical prostate cancer reveals targetable alterations in membrane lipid composition.
Butler LM, Mah CY, Machiels J, Vincent AD, Irani S, Mutuku SM, Spotbeen X, Bagadi M, Waltregny D, Moldovan M, Dehairs J, Vanderhoydonc F, Bloch K, Das R, Stahl J, Kench JG, Gevaert T, Derua R, Waelkens E, Nassar ZD, Selth LA, Trim PJ, Snel MF, Lynn DJ, Tilley WD, Horvath LG, Centenera MM, Swinnen JV.
Cancer Res. 2021 Aug 6:canres.3863.2020. doi: 10.1158/0008-5472.CAN-20-3863. PMID: 34362796
Contact: Lisa Butler
ELOVL5: Inching closer to a new therapeutic strategy for prostate cancer
ELOVL5 is a critical and targetable fatty acid elongase in prostate cancer
Centenera MM, Scott JS, Machiels J, Nassar ZD, Miller DC, Zininos I, Dehairs J, Burvenich IJG, Zadra G, Chetta P, Bango C, Evergren E, Ryan NK, Gillis JL, Mah CY, Tieu T, Hanson AR, Carelli R, Bloch K, Panagopoulos V, Waelkens E, Derua R, Williams ED, Evdokioou A, Cifuentes-Rius A, Voelcker NH, Mills IG, Tilley WD, Scott AM, Loda M, Selth LA, Swinnen JV, Butler LM. Cancer Res. 2021 Feb 5:canres.2511.2020. doi: 10.1158/0008-5472.CAN-20-2511.
Contact: Maggie Centenera
Review: Fatty acid metabolism in cancer
The diversity and breadth of cancer cell fatty acid metabolism.
Nagarajan SR, Butler LM, Hoy AJ.
Cancer Metab. 2021 Jan 7;9(1):2. doi: 10.1186/s40170-020-00237-2. (Review)
Contact: Lisa Butler
miR-194: a potential therapeutic target to prevent drug resistant prostate cancer
Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer.
Fernandes RC, Toubia J, Townley S, Hanson AR, Dredge BK, Pillman KA, Bert AG, Winter JM, Iggo R, Das R, Obinata D; MURAL investigators, Sandhu S, Risbridger GP, Taylor RA, Lawrence MG, Butler LM, Zoubeidi A, Gregory PA, Tilley WD, Hickey TE, Goodall GJ, Selth LA. Cell Rep. 2021 Jan 5;34(1):108585. doi: 10.1016/j.celrep.2020.108585.
Contact: Luke Selth