Farmers co-design of ifarmwell health and wellbeing platform

Farmers co-design of ifarmwell health and wellbeing platform

Combining Farmers' Preferences With Evidence-Based Strategies to Prevent and Lower Farmers' Distress: Co-design and Acceptability Testing of ifarmwell.
Gunn KM, Skaczkowski G, Dollman J, Vincent AD, Short CE, Brumby S, Barrett A, Harrison N, Turnbull D.JMIR Hum Factors. 2022 Jan 11;9(1):e27631. doi: 10.2196/27631.PMID: 35014963
Contact: Kate Gunn

Lingering effects of testosterone injections lead to long delay in recovery of male reproductive function

Lingering effects of testosterone injections lead to long delay in recovery of male reproductive function

Recovery of Male Reproductive Function After Ceasing Prolonged Testosterone Undecanoate Injections
Handelsman DJ, Desai R, Conway AJ, Shankara-Narayana N, Stuckey BG, Inder WJ, Grossmann M, Yeap BB, Jesudason D, Ly LP, Bracken K, Wittert GA. Eur J Endocrinol. 2022 Jan 1:EJE-21-0608.R2. doi: 10.1530/EJE-21-0608. Online ahead of print.PMID: 35000898
Contact: Gary Wittert

Testosterone concentration associated with dementia in men: The UK Biobank prospective cohort study

Testosterone concentration associated with dementia in men: The UK Biobank prospective cohort study

Lower serum testosterone concentrations are associated with a higher incidence of dementia in men: The UK Biobank prospective cohort study.
Marriott RJ, Murray K, Flicker L, Hankey GJ, Matsumoto AM, Dwivedi G, Antonio L, Almeida OP, Bhasin S, Dobs AS, Handelsman DJ, Haring R, O'Neill TW, Ohlsson C, Orwoll ES, Vanderschueren D, Wittert GA, Wu FCW, Yeap BB. Alzheimers Dement. 2022 Jan 3. doi: 10.1002/alz.12529. Online ahead of print.PMID: 34978125
Contact: Gary Wittert

Relevance of testosterone & SHBG in cardiovascular disease in men

Relevance of testosterone & SHBG in cardiovascular disease in men

Associations of Serum Testosterone and Sex Hormone-Binding Globulin With Incident Cardiovascular Events in Middle-Aged to Older Men.
Yeap BB, Marriott RJ, Antonio L, Raj S, Dwivedi G, Reid CM, Anawalt BD, Bhasin S, Dobs AS, Handelsman DJ, Hankey GJ, Haring R, Matsumoto AM, Norman PE, O'Neill TW, Ohlsson C, Orwoll ES, Vanderschueren D, Wittert GA, Wu FCW, Murray K. Ann Intern Med. 2021 Dec 28. doi: 10.7326/M21-0551. Online ahead of print.PMID: 34958606
Contact: Gary WIttert

Links between depression and lower urinary tract symptoms in men: screening implications

Links between depression and lower urinary tract symptoms in men: screening implications

The bidirectional association between depression and lower urinary tract symptoms (LUTS) in men: A systematic review and meta-analysis of observational studies.
Martin SA, Tully PJ, Kahokehr AA, Jay A, Wittert GA. Neurourol Urodyn. 2022 Jan 12. doi: 10.1002/nau.24868. Online ahead of print.PMID: 35019156 Review.
Contact: Sean Martin

Dr Sean Martin appointed as Project Lead for the Ten to Men Study

The Centre is pleased to congratulate Dr Sean Martin (FCMHW Post-doctoral Research Fellow) on his appointment as the Project Lead for the Ten to Men (TTM) Study based at the Australian Institute of Family Studies (https://aifs.gov.au/projects/ten-to-men).

The TTM study is funded by the Commonwealth Government and is a key deliverable of the National Men’s Health Strategy.

With over 16,000 participants aged 10-55 years at recruitment the TTM study is the largest male-only cohort study in the world.

It focuses on key social, economic, environmental and behavioural factors that influence the development of boys into men. Within government, it also has a core responsibility to report on, and develop new policies, that influence the length and quality of life of Australian males.

Dr Martin has been a member of the Centre since its inception in 2007, and has been the Manager of the Centre’s Florey Adelaide Male Ageing cohort Study (FAMAS) which turns 20 years this year. FAMAS was harmonised with another cohort to create the MAILES (Men Androgen Inflammation Lifestyle Environment and Stress) study, and is one of the most comprehensive and longest-running biomedical longitudinal cohort studies of male health and wellbeing in Australia, based in the FCMHW at the University of Adelaide and SAHMRI.

Dr Martin will continue his affiliation with the Centre as an academic titleholder of the University of Adelaide.

Sean will start this new exciting position in Feb 2022. He may be contacted at Sean.Martin@aifs.gov.au.

Abnormalities of sleep spindles, important for cognition, due to obstructive sleep apnoea

Abnormalities of sleep spindles, important for cognition, due to obstructive sleep apnoea

The association between obstructive sleep apnea and sleep spindles in middle-aged and older men: A community-based cohort study.
Parker JL, Melaku YA, D'Rozario AL, Wittert GA, Martin SA, Catcheside PG, Lechat B, Teare AJ, Adams RJ, Appleton SL, Vakulin A. Sleep. 2021 Nov 29:zsab282. doi: 10.1093/sleep/zsab282.PMID: 34850237.
Contact: Sarah Appleton

Fatty acid oxidation inhibition to treat advanced prostate cancer

Fatty acid oxidation inhibition to treat advanced prostate cancer

With progressed prostate cancer, men are no longer responding to the standard anti-androgen drug therapy. While developing new drugs often can take 15 years, this program will reduce this timeframe by aiming to re-purpose existing lipid-modifying medicines. We aim to take our laboratory findings into a proof-of-concept clinical trial to test whether trimetazidine is safe and effective in treating men on ADT, to prevent or delay the onset of lethal castrate resistant prostate cancer.

Through this trial we aim for a potential new therapeutic approach using existing drugs used to treat cardio-metabolic disease to prevent lethal prostate cancer, reduced drug-related toxicities in men being treated for prostate cancer, and Improved length and quality of life for men living with advanced prostate cancer.

Contact: Dr Zeyad Nassar

Improving precision medicine for men being treated for prostate cancer

Improving precision medicine for men being treated for prostate cancer

The aim of this project is to determine the impact of commonly prescribed classes of concomitant non-cancer medicines (i.e.antibiotics, proton pump inhibitors, lipid- and blood glucose-lowering medications) on the efficacy of treatments for metastatic prostate cancer. To achieve this, we will exploit large clinical trial datasets, sophisticated data analytic methods (e.g. machine learning) and biologically-informed models.

Contact: Dr Ashley Hopkins

Digitally driven pathways to optimise use and outcomes of primary care for men

Digitally driven pathways to optimise use and outcomes of  primary care for men

This research aims to translate the Centre’s research into an impactful health service integration program targeting the patient-GP interface, arming men with the knowledge, motivation, and agency to recognize symptoms and health behaviours as prompts to engage with primary health care services, and providing men and GPs with tools that optimise the outcomes of that engagement.

Contact: Professor Gary Wittert

Improving uptake of prostate cancer screening in men from culturally and linguistically diverse backgrounds.

Improving uptake of prostate cancer screening in men from  culturally and linguistically diverse backgrounds.

We will partner with researchers and community outreach officers at Cancer Council SA (lead by Dr Jess Loyer), the Multicultural Communities of South Australia Men’s Group who are investigating barriers to engagement with cancer control programs among CALD communities.

This program aims to adapt the current RACGP prostate cancer screening decision-making tool to be culturally sensitive and meet the needs of men from CALD backgrounds and improve the uptake of PSA screening which will facilitate early detection and treatment/monitoring of prostate cancer.

Contact: Dr Norma Bulamu

Clinical workforce development: Healthy Male-Bellberry Clinical Training Fellowship in Men’s Health

Clinical workforce development:  Healthy Male-Bellberry Clinical  Training Fellowship in Men’s Health

This program is a 1-year South-Australian-based clinical training fellowship in andrology and Men’s Health, delivered in association with Healthy Male (Andrology Australia) to develop a dedicated men’s health clinical sub-specialty workforce and services.

Contact: Professor Gary Wittert

Safety & useability established for ExerciseGuide for men with metastatic prostate Ca

Safety & useability established for ExerciseGuide for men with metastatic prostate Ca

Acceptability and preliminary efficacy of a web- and telephone-based personalised exercise intervention for individuals with metastatic prostate cancer: The ExerciseGuide pilot randomised controlled trial. Cancers (Basel). 2021 Nov 25;13(23):5925. doi: 10.3390/cancers13235925. PMID: 34885036.
Evans HEL, Galvão DA, Forbes CC, Girard D, Vandelanotte C, Newton RU, Vincent AD, Wittert G, Kichenadasse G, Chambers S, Brook N, Short CE.
Contact: Holly Evans

Troubles-telling an important self-help tool for anxiety

Troubles-telling an important self-help tool for anxiety