The androgen receptor is a tumor suppressor in estrogen receptor-positive breast cancer
Hickey TE, Selth LA, Chia KM, Laven-Law G, Milioli HH, Roden D, Jindal S, Hui M, Finlay-Schultz J, Ebrahimie E, Birrell SN, Stelloo S, Iggo R, Alexandrou S, Caldon CE, Abdel-Fatah TM, Ellis IO, Zwart W, Palmieri C, Sartorius CA, Swarbrick A, Lim E, Carroll JS, Tilley WD. Nat Med. 2021 Jan 18. doi: 10.1038/s41591-020-01168-7.
Contact: Wayne Tilley
Introducing Douglas Clinch - Aboriginal and Torres Strait Islander Men’s Health
Aboriginal and Torres Strait Islander Men’s Health
We are very pleased to welcome Mr Douglas (Dougie) Clinch as a member of the Centre.
Dougie is a Ngarrindjeri man through his mother, whose traditional lands include the lower Murray River, western Fleurieu Peninsula, and the Coorong in South Australia; and through his father he is a Badimaya man of the Yamatji people, whose lands include the Mid-west region of Western Australia. He was born and raised on Kaurna Country and has lived in the southern suburbs of Adelaide for much of his life.
Dougie has worked as a Project Officer at the South Australian Health and Medical Research Institute (SAHMRI) for nearly four years, spending most of that time with the SA Aboriginal Chronic Disease Consortium in the Aboriginal Health Equity unit, also known as Wardliparingga
Towards the end of 2020 Dougie began his transition over to the Aboriginal and Torres Strait Islander Men’s Health program, joining Dr Kootsy Canuto’s team as a dedicated Engagement and Project Officer.
Despite most of the work still being ahead of him, Dougie has been busy engaging with stakeholders of Aboriginal and Torres Strait Islander men’s health to both understand the landscape across South Australia and building meaningful relationships with all stakeholders, including most importantly, communities.
Dougie will provide Aboriginal leadership in brokering and maintaining social and health service sector relationships during co-design, implementation and evaluation activities of the Aboriginal and Torres Strait Islander Men’s Health research program. This will require ongoing and regular engagement with Aboriginal communities across South Australia. In addition, Dougie will contribute to co-designing strategies to increase and improve engagement and utilisation of primary health care services by Aboriginal and Torres Strait Islander men in South Australia.
Contact: Douglas Clinch
Review: Fatty acid metabolism in cancer
The diversity and breadth of cancer cell fatty acid metabolism.
Nagarajan SR, Butler LM, Hoy AJ.
Cancer Metab. 2021 Jan 7;9(1):2. doi: 10.1186/s40170-020-00237-2. (Review)
Contact: Lisa Butler
miR-194: a potential therapeutic target to prevent drug resistant prostate cancer
Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer.
Fernandes RC, Toubia J, Townley S, Hanson AR, Dredge BK, Pillman KA, Bert AG, Winter JM, Iggo R, Das R, Obinata D; MURAL investigators, Sandhu S, Risbridger GP, Taylor RA, Lawrence MG, Butler LM, Zoubeidi A, Gregory PA, Tilley WD, Hickey TE, Goodall GJ, Selth LA. Cell Rep. 2021 Jan 5;34(1):108585. doi: 10.1016/j.celrep.2020.108585.
Contact: Luke Selth
IVF for female factor infertility (male fertile) is superior
Comparison of in vitro fertilisation/intracytoplasmic sperm injection on live birth rates in couples with non-male factor infertility and advanced maternal age.
McPherson NO, Vincent AD, Pacella-Ince L, Tremellen K.J Assist Reprod Genet. 2021 Jan 7. doi: 10.1007/s10815-020-02026-8.
Contact: Nicole McPherson
Testosterone + lifestyle program reduces the risk of T2DM in men
Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial.
Wittert G, Bracken K, Robledo KP, Grossmann M, Yeap BB, Handelsman DJ, Stuckey B, Conway A, Inder W, McLachlan R, Allan C, Jesudason D, Fui MNT, Hague W, Jenkins A, Daniel M, Gebski V, Keech A. Lancet Diabetes Endocrinol. 2021 Jan;9(1):32-45. doi: 10.1016/S2213-8587(20)30367-3.
Contact: Gary Wittert
Congratulations 2020-21 Summer Vacation Research Scholarship awardees
Masculinity and mental health: shaping the attitudes, behaviours and education of young men through sport
This Program aims to listen to the voices of young males around mental health and wellbeing within masculinised sporting cultures, explore the way in which sporting clubs work with young males around mental health and wellbeing, investigate the way in which masculinities are created, maintained, and perpetuated within masculinized sporting clubs, and promote the importance of mental health and wellbeing as a key element of sporting club culture.
Contact: Murray Drummond
Maximising the effectiveness of psychological treatment for young men with psychosis
The metacognitive training (MCT) programme is an effective psychological treatment for reducing delusional symptoms and may be particularly effective in young men. This is due to MCT’s unique focuses on the underlying problematic thinking styles responsible for delusions, rather than directly challenging these beliefs, which makes it a less confrontational approach.
Contact: Ryan Balzan
This program’s focus is on de-stigmatising psychosis and its youth-friendly audio-visual delivery to help foster a strong therapeutic alliance that will also help young men stay engaged with therapy and could improve their long-term prognosis.
Using COVID-19 pandemic data on mental and physical health to help Australian men
Using COVID-19 response data collected from men in the Florey Adelaide Male Ageing Study (FAMAS) & the North West Adelaide Health Study (NWAHS), the aim is to develop a detailed understanding of the acute and medium-term economic drivers of mental and physical health maintenance in well-characterised, representative cohorts of men.
Contact: Prof Robert Adams
We will continue to collect the stories/accounts of male veteran suicide from families or survivors, and use this to identify i) the service-related contexts, ii) post service-related contexts, iii) the family and social support elements, iv) the institutional support elements, and v) mental and physical health elements of men’s suicide or attempted suicide.
Veteran suicide: Men, Health, Service
This program hopes to continue to formally define the relationship between the ideals of manhood, the impacts of military training and service and their relationship with poor mental health or moral injury leading to suicide attempt or death.
Contact: Ben Wadham
We will continue to collect the stories/accounts of male veteran suicide from families or survivors, and use this to identify i) the service-related contexts, ii) post service-related contexts, iii) the family and social support elements, iv) the institutional support elements, and v) mental and physical health elements of men’s suicide or attempted suicide.
Translation of knowledge into practice: building the wellbeing of Aboriginal men and boys
The aim of this program is to translate ecological maps of risk and protective factors for wellbeing in Aboriginal men and boys into health promotion and prevention activities in SA through trialling the use of an ecological framework and knowledge interface processes as tools to improve the wellbeing of First Nations men and boys.
The program will be led by Aboriginal academics and informed by Indigenous knowledge of health and wellbeing. Further, community engagement will empower communities to participate in the development of resources to support the social and emotional wellbeing of their men and boys.
Contact: Tamara Mackean
Deep decision-making for prostate tumour Gleason Score 7
This project, which brings together expertise in clinical pathology, machine learning, statistics and computer science, aims to use a Deep Learning approach to analyse prostate biopsy images to better distinguish between Gleason 3+4 and 4+3 more reliably.
Contact: Dr Gobert lee
Quality of life assessment in routine care for prostate cancer
This program aims to design, implement and evaluate a framework for incorporating at the start and along the care continuum disease specific and generic QoL assessment into routine clinical care for men prostate cancer.
Contact: Dr Norma Bulamu
Investigating the effects of androgen therapies on the prostate immune system
Immunotherapy approaches for prostate cancer have been largely unsuccessful, despite many clinical trials. We propose that harnessing the immune system to treat prostate cancer first requires a better understanding of the unique biology of this disease. The objective of this research program is to investigate the interplay between androgen receptor signalling and immunity in prostate cancer
Contact: A/Prof Luke Selth