The androgen receptor: A promising treatment for breast cancer

The androgen receptor: A promising treatment for breast cancer

The androgen receptor is a tumor suppressor in estrogen receptor-positive breast cancer
Hickey TE, Selth LA, Chia KM, Laven-Law G, Milioli HH, Roden D, Jindal S, Hui M, Finlay-Schultz J, Ebrahimie E, Birrell SN, Stelloo S, Iggo R, Alexandrou S, Caldon CE, Abdel-Fatah TM, Ellis IO, Zwart W, Palmieri C, Sartorius CA, Swarbrick A, Lim E, Carroll JS, Tilley WD. Nat Med. 2021 Jan 18. doi: 10.1038/s41591-020-01168-7.
Contact: Wayne Tilley

Introducing Douglas Clinch - Aboriginal and Torres Strait Islander Men’s Health

Aboriginal and Torres Strait Islander Men’s Health

Aboriginal and Torres Strait Islander Men’s Health

We are very pleased to welcome Mr Douglas (Dougie) Clinch as a member of the Centre.

Dougie is a Ngarrindjeri man through his mother, whose traditional lands include the lower Murray River, western Fleurieu Peninsula, and the Coorong in South Australia; and through his father he is a Badimaya man of the Yamatji people, whose lands include the Mid-west region of Western Australia. He was born and raised on Kaurna Country and has lived in the southern suburbs of Adelaide for much of his life.

Dougie has worked as a Project Officer at the South Australian Health and Medical Research Institute (SAHMRI) for nearly four years, spending most of that time with the SA Aboriginal Chronic Disease Consortium in the Aboriginal Health Equity unit, also known as Wardliparingga

Towards the end of 2020 Dougie began his transition over to the Aboriginal and Torres Strait Islander Men’s Health program, joining Dr Kootsy Canuto’s team as a dedicated Engagement and Project Officer.

Despite most of the work still being ahead of him, Dougie has been busy engaging with stakeholders of Aboriginal and Torres Strait Islander men’s health to both understand the landscape across South Australia and building meaningful relationships with all stakeholders, including most importantly, communities.

Dougie will provide Aboriginal leadership in brokering and maintaining social and health service sector relationships during co-design, implementation and evaluation activities of the Aboriginal and Torres Strait Islander Men’s Health research program. This will require ongoing and regular engagement  with Aboriginal communities across South Australia. In addition, Dougie will contribute to co-designing strategies to increase and improve engagement and utilisation  of primary health care services by Aboriginal and Torres Strait Islander men in South Australia.

Contact: Douglas Clinch

miR-194: a potential therapeutic target to prevent drug resistant prostate cancer

miR-194: a potential therapeutic target to prevent drug resistant prostate cancer

Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer.
Fernandes RC, Toubia J, Townley S, Hanson AR, Dredge BK, Pillman KA, Bert AG, Winter JM, Iggo R, Das R, Obinata D; MURAL investigators, Sandhu S, Risbridger GP, Taylor RA, Lawrence MG, Butler LM, Zoubeidi A, Gregory PA, Tilley WD, Hickey TE, Goodall GJ, Selth LA. Cell Rep. 2021 Jan 5;34(1):108585. doi: 10.1016/j.celrep.2020.108585.
Contact: Luke Selth

IVF for female factor infertility (male fertile) is superior

IVF for female factor infertility (male fertile) is superior

Comparison of in vitro fertilisation/intracytoplasmic sperm injection on live birth rates in couples with non-male factor infertility and advanced maternal age.
McPherson NO, Vincent AD, Pacella-Ince L, Tremellen K.J Assist Reprod Genet. 2021 Jan 7. doi: 10.1007/s10815-020-02026-8.
Contact: Nicole McPherson

Testosterone + lifestyle program reduces the risk of T2DM in men

Testosterone + lifestyle program reduces the risk of T2DM in men

Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial.
Wittert G, Bracken K, Robledo KP, Grossmann M, Yeap BB, Handelsman DJ, Stuckey B, Conway A, Inder W, McLachlan R, Allan C, Jesudason D, Fui MNT, Hague W, Jenkins A, Daniel M, Gebski V, Keech A. Lancet Diabetes Endocrinol. 2021 Jan;9(1):32-45. doi: 10.1016/S2213-8587(20)30367-3.
Contact: Gary Wittert

Masculinity and mental health: shaping the attitudes, behaviours and education of young men through sport

 Masculinity and mental health: shaping the attitudes, behaviours and education of young men through sport

This Program aims to listen to the voices of young males around mental health and wellbeing within masculinised sporting cultures, explore the way in which sporting clubs work with young males around mental health and wellbeing, investigate the way in which masculinities are created, maintained, and perpetuated within masculinized sporting clubs, and promote the importance of mental health and wellbeing as a key element of sporting club culture.

Contact: Murray Drummond

Maximising the effectiveness of psychological treatment for young men with psychosis

Maximising the effectiveness of psychological treatment for young men with psychosis

The metacognitive training (MCT) programme is an effective psychological treatment for reducing delusional symptoms and may be particularly effective in young men. This is due to MCT’s unique focuses on the underlying problematic thinking styles responsible for delusions, rather than directly challenging these beliefs, which makes it a less confrontational approach.

Contact: Ryan Balzan

This program’s focus is on de-stigmatising psychosis and its youth-friendly audio-visual delivery to help foster a strong therapeutic alliance that will also help young men stay engaged with therapy and could improve their long-term prognosis.

Using COVID-19 pandemic data on mental and physical health to help Australian men

Using COVID-19 pandemic data on mental and physical health to help Australian men

Using COVID-19 response data collected from men in the Florey Adelaide Male Ageing Study (FAMAS) & the North West Adelaide Health Study (NWAHS), the aim is to develop a detailed understanding of the acute and medium-term economic drivers of mental and physical health maintenance in well-characterised, representative cohorts of men.

Contact: Prof Robert Adams

We will continue to collect the stories/accounts of male veteran suicide from families or survivors, and use this to identify i) the service-related contexts, ii) post service-related contexts, iii) the family and social support elements, iv) the institutional support elements, and v) mental and physical health elements of men’s suicide or attempted suicide.

Veteran suicide: Men, Health, Service

Veteran suicide: Men, Health, Service

This program hopes to continue to formally define the relationship between the ideals of manhood, the impacts of military training and service and their relationship with poor mental health or moral injury leading to suicide attempt or death.

Contact: Ben Wadham

We will continue to collect the stories/accounts of male veteran suicide from families or survivors, and use this to identify i) the service-related contexts, ii) post service-related contexts, iii) the family and social support elements, iv) the institutional support elements, and v) mental and physical health elements of men’s suicide or attempted suicide.

Translation of knowledge into practice: building the wellbeing of Aboriginal men and boys

Translation of knowledge into practice: building the wellbeing of Aboriginal men and boys

The aim of this program is to translate ecological maps of risk and protective factors for wellbeing in Aboriginal men and boys into health promotion and prevention activities in SA through trialling the use of an ecological framework and knowledge interface processes as tools to improve the wellbeing of First Nations men and boys.

The program will be led by Aboriginal academics and informed by Indigenous knowledge of health and wellbeing. Further, community engagement will empower communities to participate in the development of resources to support the social and emotional wellbeing of their men and boys.

Contact: Tamara Mackean

Investigating the effects of androgen therapies on the prostate immune system

Investigating the effects of androgen therapies on the prostate immune system

Immunotherapy approaches for prostate cancer have been largely unsuccessful, despite many clinical trials. We propose that harnessing the immune system to treat prostate cancer first requires a better understanding of the unique biology of this disease. The objective of this research program is to investigate the interplay between androgen receptor signalling and immunity in prostate cancer

Contact: A/Prof Luke Selth